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Comment on “The Arabidopsis Circadian Clock Incorporates a cADPR-Based Feedback Loop”

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Science  09 Oct 2009:
Vol. 326, Issue 5950, pp. 230
DOI: 10.1126/science.1169503

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Dodd et al. (Reports, 14 December 2007, p. 1789) reported that the Arabidopsis circadian clock incorporates the signaling molecule cyclic adenosine diphosphate ribose (cADPR). In contrast, we found that there is no rhythm of cADPR levels nor are there any significant effects on the rhythm by cADPR overexpression, thus raising questions about the conclusions of Dodd et al.

  • * Present address: Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA.

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