Technical Comments

Response to Comment on “The Arabidopsis Circadian Clock Incorporates a cADPR-Based Feedback Loop”

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Science  09 Oct 2009:
Vol. 326, Issue 5950, pp. 230
DOI: 10.1126/science.1169736

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Xu et al. were unable to measure circadian oscillations of cyclic adenosine diphosphate ribose (cADPR). Their experiments showing very low concentrations of cADPR lack appropriate controls, which suggests that technical limitations might explain their negative result. Xu et al. also report that chemically induced ADP ribosyl cyclase did not alter clock function, which exactly replicates our findings.

  • * Present address: Department of Biology, University of York, York YO10 5YW, UK.

  • Present address: School of Biosciences, University of Exeter, Exeter EX4 4QD, UK.

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