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Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

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Science  09 Oct 2009:
Vol. 326, Issue 5950, pp. 289-293
DOI: 10.1126/science.1181369

Article Information

vol. 326 no. 5950 289-293

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History: 
  • Received for publication September 1, 2009
  • Accepted for publication September 18, 2009

Author Information

  1. Erez Lieberman-Aiden1,2,3,4,*,
  2. Nynke L. van Berkum5,*,
  3. Louise Williams1,
  4. Maxim Imakaev2,
  5. Tobias Ragoczy6,7,
  6. Agnes Telling6,7,
  7. Ido Amit1,
  8. Bryan R. Lajoie5,
  9. Peter J. Sabo8,
  10. Michael O. Dorschner8,
  11. Richard Sandstrom8,
  12. Bradley Bernstein1,9,
  13. M. A. Bender10,
  14. Mark Groudine6,7,
  15. Andreas Gnirke1,
  16. John Stamatoyannopoulos8,
  17. Leonid A. Mirny2,11,
  18. Eric S. Lander1,12,13,,
  19. Job Dekker5,
  1. 1Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), MA 02139, USA.
  2. 2Division of Health Sciences and Technology, MIT, Cambridge, MA 02139, USA.
  3. 3Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, Cambridge, MA 02138, USA.
  4. 4Department of Applied Mathematics, Harvard University, Cambridge, MA 02138, USA.
  5. 5Program in Gene Function and Expression and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  6. 6Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  7. 7Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA.
  8. 8Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
  9. 9Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
  10. 10Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.
  11. 11Department of Physics, MIT, Cambridge, MA 02139, USA.
  12. 12Department of Biology, MIT, Cambridge, MA 02139, USA.
  13. 13Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  1. To whom correspondence should be addressed. E-mail: lander{at}broadinstitute.org (E.S.L.); job.dekker{at}umassmed.edu (J.D.)

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