Feeding the Clock

See allHide authors and affiliations

Science  16 Oct 2009:
Vol. 326, Issue 5951, pp. 378-379
DOI: 10.1126/science.1181278

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


In mammals, sleeping, feeding, and most other physiological processes are influenced by a circadian system and therefore display daily oscillations. These rhythms are generated by self-sustained and cell-autonomous molecular clocks that exist in virtually all cell types. A “master clock” located in the brain's suprachiasmatic nucleus (SCN) can synchronize these peripheral clocks, but for many organs, feeding-fasting rhythms are the dominant zeitgebers (timing cues) (1, 2). On page 437 of this issue, Lamia et al. propose a molecular mechanism through which metabolic cycles may interact with the circadian clockwork circuitry. They show that an enzyme that responds to nutrient availability—adenosine monophosphate–activated protein kinase (AMPK)—directly phosphorylates the core clock protein cryptochrome 1 (CRY1), thereby marking it for degradation (3).