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Science  23 Oct 2009:
Vol. 326, Issue 5952, pp. 601
DOI: 10.1126/science.326_601a

Drug Discovery Kits

The Maybridge Quick2Lead Compound Kits are designed to save time and money by enabling rapid compound library synthesis around bioactive "hits" from screening assays. The kits are made up of preweighed, diverse building-block selections, facilitating rapid capture of structure-activity data from the closely related structural analogs within the library. Quick2Lead Compound Kits are available as five functionality-based kits, with each containing 48 carefully selected compounds. This enables the exploration of a wide area of chemical space to maximize credible structure-activity data acquisition for the successful conversion of an initial hit into a genuine, optimizable lead. Because these compounds are all preweighed, the kits are ready to use by simply adding solvent and transferring to a synthesizer. The five functional groups available are carboxylic acids, sulfonyl chlorides, amines, anilines, and boronic acids.

Direct Activity Assay

Direct Activity Assay kits for methyltransferases—protein arginine methyltransferase 1 (PRMT1), PRMT3, PRMT5, and Set 7/9—have been developed to enable the measurement of enzyme activity using purified enzymes or enzyme-containing extracts. Each kit is supplied in a 96-well plate precoated with peptide substrates, an antibody against the specific methylated target, a secondary europium-labeled antibody, S-adenosylmethionine, methyltransferase assay buffer, and purified enzyme for 100 enzyme reactions. The keys to the kits are the highly specific antibodies that recognize methylated residues of the different substrates. They require only a few simple steps for detection of methyltransferase activity.

Laser Microdissection

The Leica LMD6500 microdissection tool can distinguish between relevant and irrelevant cells and tissues. It allows forensic DNA technologists to selectively and routinely analyze microscopic regions of interest down to a single cell to obtain results and make determinations that are relevant, reproducible, and specific. The laser beam movement of the Leica LMD6500 is controlled by high-precision optics, and the microscope stage and the sample are both fixed. This combination allows precise cutting accuracy at high magnifications, as well as high cutting speed at low magnifications. Both are prerequisites to obtain a homogeneous material for downstream analysis and reliable results. The laser microdissection makes use of a simple method of gravity to gently collect the samples. The dissected material, no matter its size or shape, is collected in a contact-free, contamination-free manner.

Polarization Microscopy

The Axio Imager 2 systems are meant to meet user demand for a versatile and easy-to-use polarization microscope. The systems exhibit high resolution and offer all contrasting and measuring techniques used in polarization microscopy. They provide user-friendly operation via a touchscreen, an encoded nosepiece, and many automated functions for convenience and flexibility. These upgradable microscopes offer the option of encoded, partly to fully motorized components for both traditional and future applications. They feature the optimized Infinity Color & Contrast Corrected System beam path and high-contrast objectives. They also have the capability to combine reflected and transmitted light.

Cell Analyzer

The BD LSRFortessa cell analyzer is a compact system that provides the ability to conduct complex multicolor flow cytometry experiments. It supports up to five lasers and 18 colors simultaneously in a benchtop footprint that is significantly smaller than the BD LSR II cell analyzer. Researchers can choose from 30 positions for detectors and 11 laser wavelengths and multiple power options to configure a system that meets their precise assay requirements.

Circularization of Single-Stranded DNA

CircLigase II ssDNA Ligase efficiently catalyzes the circularization of single-stranded (ss) DNA greater than 15 bases without the need for oligonucleotide bridges. Virtually no linear or circular concatamers are produced by the enzyme. CircLigase II Ligase is an improved version of the original CircLigase enzyme, and is suitable for preparing circular templates from oligonucleotides or single-stranded complementary DNA for rolling-circle replication or rolling-circle transcription assays.

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