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Science  30 Oct 2009:
Vol. 326, Issue 5953, pp. 737
DOI: 10.1126/science.326_737a

Large Incubator

The CB 53 Incubator offers a 1.9-cubic-foot capacity in a compact footprint to reduce operating costs and conserve space. Hot-air chamber sterilization at 180°C makes it particularly well suited for applications in cell and tissue culture, as well as for in vitro fertilization laboratories. The Permadry condensation-free, double-pan humidification system maintains dry interior walls while the incubator operates at a relative humidity of more than 95 percent. The water level can be visually inspected, and changing the water or refilling the water pan is easy. A mixture of carbon dioxide and air is injected into the inner chamber through a cross-flow mixing valve. The mixture is distributed homogeneously because the inner chamber is under slight vacuum, which generates a Venturi effect. The need for an internal fan, which creates turbulence and complicates cleaning, is eliminated.

Toxicity Reporter Assay Panel

ToxReporter is a new panel of engineered cell lines and assays that can screen compounds for toxicity early in the drug discovery process. The ToxReporter panel detects a variety of cellular responses linked to toxic stresses, including oxidative stress and antioxidant response, inflammatory response, cell cycle control, DNA damage and apoptosis, hypoxia and angiogenesis, and stress responses. The assays are flexible; researchers can test multiple compounds or multiple cell lines using a single enzyme-linked immunosorbent assay. The assays are quantitative and can be performed at multiple time points.

LC-MS/MS System

The TSQ Vantage is a liquid chromatography–tandem mass spectrometry (LC-MS/MS) system that delivers up to 10 times more sensitivity than any other triple quadrupole instrument on the market, without a commensurate increase in noise. Breakthroughs in ionization efficiency and ion transmission have given the TSQ Vantage improved signal-to-noise performance, providing better reproducibility and precision in the quantitative analysis of small molecules, biomolecules, and peptides. A new S-Lens ion optics system makes use of novel electrostatic field technology to capture virtually every ion and transfer it into the HyperQuad quadrupole mass analyzer. The S-Lens is an advance over high-pressure, skimmer-based ion source designs because it eliminates mass discrimination and lowers the gas load on the expensive turbo-molecular pumps. This innovation keeps the ion optical path cleaner, for a longer period of time, while maintaining sensitivity.

Liquid Chromatography System

The Flexar liquid chromatography platform incorporates a new ergonomic industrial design and delivers a wide range of pressure options to address the increasingly demanding application needs of high-pressure liquid chromatography laboratories. This multitiered platform offers solutions from semiprep to ultrahigh-pressure liquid chromatography (UHPLC). It is controlled by the new Chromera Chromatography Data System, which was built from the ground up to offer an easy approach to instrument control and chromatographic data processing. The FX-15 UHPLC system features small particle–size columns (less than 2 µm) to offer new possibilities for resolution and separations, as well as fast analysis time. The system can reduce mobile phase solvent consumption by as much as 15-fold. The Chromera software allows users to easily control instruments, rapidly visualize data, and efficiently communicate results.

Co-Culturing Technology

Integrated Discrete Multiple Organ Co-Culture (IdMOC) is a patented technology allowing coculturing of multiple cell lines in the same culture dish as physically separated but interconnected cultures, modeling human or animals in vivo with multiple organs connected by the systemic circulation. IdMOC makes use of a "wells-in-a-well" concept, with multiple small wells inside a larger containing well. The cells are physically discrete cultures in the inner wells, with interconnection achieved by an overlying medium in the containing well, covering the inner wells. The system can be used to evaluate drug distribution, multiple organ metabolism, and toxicity, as well as other applications.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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