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Errors in Chemistry Claims Cast Doubt on Reactome Paper

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Science  01 Jan 2010:
Vol. 327, Issue 5961, pp. 22-23
DOI: 10.1126/science.327.5961.22-b

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Summary

A newly developed research tool called a reactome array, which has attracted widespread interest from biologists, has come under intense fire from scientists who say the description of the device in the 9 October issue of Science includes "impossible" chemical reactions and makes little sense. The publication drew immediate attention because the array promises to establish the functions of a myriad of enzymes and probe the metabolism of bacteria and other kinds of cells. Last week, Science acknowledged the furor, publishing online an "Editorial Expression of Concern" in which the journal's editor-in-chief, Bruce Alberts, notes that "serious questions have been raised about the methods and data presented."