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Science  08 Jan 2010:
Vol. 327, Issue 5962, pp. 221
DOI: 10.1126/science.327.5962.221-a

Peptide Synthesizer

The Sonata XT peptide synthesizer is designed for 0.5 mmol to 200 mmol synthesis scales (up to 400 g of resin). It features a single glass reaction vessel in multiple sizes (200 mL, 500 mL, 1.2 L, 2 L, 3.2 L, and 4.2 L), 20 amino acid bottles (500 mL or 1 L), and seven solvent bottle positions. Flexible software makes it easy to scale up any protocol. The Sonata XT can be used for batch or continuous flow syntheses and features timed or volumetric deliveries and multiple mixing modes (nitrogen bubbling, vortex, and recirculation), which can be performed separately or in combination. It also features two separate waste streams to minimize disposal costs and automated cleavage. It is good-manufacturing-practices compliant.

Cross-linking Immunoprecipitation Kit

The Pierce Crosslink Immunoprecipitation (IP) Kit extends the functionality of protein A/G-based IP reactions by adding cross-linking chemistry to the procedure. The kit features an improved protocol and buffers that result in a high yield of functional antigens using small amounts of antibody (2–10 µg). The irreversible attachment of the antibody and mild elution procedures not only minimize antibody contamination in the eluted sample but also allow the resin to be reused multiple times. The kit offers convenient sample handling using spin columns that eliminate resin loss and enable more efficient separation. The procedure can be easily scaled up and works with a wide variety of antibody subclasses and species.

CE Genetic Analyzers

Two lines of capillary electrophoresis (CE) genetic analyzers have been introduced. The 3500 Dx Series is intended for clinical use and will initially be launched in specific countries within the European Union. The analyzer is intended for use by trained operators in the analysis of human DNA or RNA for the detection of genetic changes that may lead to disease presence or susceptibility. It is the first CE system to comply with the European Union In Vitro Diagnostic Medical Devices Directive 98/79/EC. The 3500 Series Genetic Analyzers, for research use only, enable researchers to run up to 1,100 sequencing or 1,200 genotyping samples per day. It features novel consumable designs, incorporating the ability to track key information with radio frequency identification tags, new optical and thermal system designs, and redesigned data collection and analysis software, which enables easy generation of cost-effective analyses and high-quality data.

Endothelial Colony Forming Cells

The Poietics ECFCs-Human Endothelial Colony Forming Cells are clonally expanded cells, isolated from human umbilical cord blood. They can be used to study many aspects of endothelial cell physiology and function, angiogenesis, and cardiovascular disease. Poietics ECFCs undergo rigorous qualification and authentication analyses during manufacturing to ensure consistency and uniformity of performance in culture.

Immersion Cooler

The FTS Flexi-Cool Immersion Cooler eliminates the inconvenience of handling dry ice or liquid nitrogen. The FTS Flexi-Cool features remote, refrigerated probes to provide reliable, rapid cooling to –100°C. The system's durable, heavy-duty refrigeration system is designed to provide years of trouble-free operation. Optional digital control with an RS-232 interface enables precise temperature control throughout the process as well as providing controlling capability and data collection from a remote location. It features a choice of three standard probes. Typical applications for the system include those involving reaction vessels, vapor trapping, laboratory dewars, differential scanning calorimeters, charge-coupled device cameras, and vapor sorption analyzers.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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