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Science  05 Feb 2010:
Vol. 327, Issue 5966, pp. 734
DOI: 10.1126/science.327.5966.734-a

Embryonic Stem Cells

Isolated from Gold Standard JAX Mice, JAX Mouse Embryonic Stem Cells are self-renewing, nontransformed cell lines established from day 3.5 blastocytes. They are capable of differentiating into all three embryonic germ layers: endoderm, ectoderm, and mesoderm. They are suitable for drug efficacy evaluation, regenerative medicine studies, and gene targeting. All three cell lines have demonstrated efficient germline transmission.

  • The Jackson Laboratory

  • For info: 800-422-6423

  • www.jax.org

Gene Function Study Kits

The cGPS (cellular genome positioning system) NIH-3T3 research kit can be used to modify the NIH-3T3 cell line to study gene functions. The NIH-3T3 cell line is commonly used in academic research laboratories as a model for studying human gene functions. The new cGPS kit allows scientists to perform targeted integration of a gene in the cells, a key step in understanding its function.

Small Cell Counter

The Scepter is an automated cell counter small enough to fit in the palm of the hand. The handheld device provides researchers with a simple and affordable option for counting cells and monitoring the health of cultures. The Scepter miniaturizes Coulter cell counting technology into a portable device the size of an automated pipette that contains sophisticated electronics for cell sensing, signal processing, and data storage. A graphical display reports the cell count and average cell volume within 20 seconds of tip insertion into a cell culture sample. The instrument also displays a histogram of cell distribution by volume or diameter for a snapshot of the health of the culture. Results can be stored in the instrument or downloaded to a computer.

Targeted siRNA and miRNA Delivery

The T3 Conjugation Kit offers effective in vivo delivery of small interfering–RNA (siRNA) and microRNA targeted to almost any cell or tissue. The kit reduces the chance of off-target effects because the systemically delivered siRNA vehicle locates and targets specific cells and tissues, which reduces the amount of siRNA required for silencing. It can also be used for targeted in vitro delivery of siRNA in primary cell lines consisting of mixed cell populations. The patent-pending T3 technology functions by conjugating a T3 Carrier to an antibody that can identify a receptor or other extracellular domain specific to the targeted cell or tissue type. The T3 Carrier-Antibody conjugate can then be loaded with siRNA and delivered systemically or locally in vivo or in vitro. Targeted cells or tissues then take up the T3 Conjugate and the siRNA is released.

Bovine Collagen

A highly purified bovine collagen at a concentration of 6 mg/ml, Nutragen is suitable for researchers who want a firmer gel for tissue culture and cell invasion studies. Nutragen collagen is approximately 97 percent Type I collagen, with the remainder being comprised of Type III collagen. It is suitable for coating of surfaces, providing preparation of thin layers for culturing cells, or use as a solid gel. It is sterile-filtered and supplied as a ready-to-use solution in a 50-ml volume.

Transfection System

The CLB-Transfection System offers reliable and cost-effective transfection of adherent and suspension cell lines. It has been tested for more than 60 different cell lines. Most cell lines are transfected with 50–90 percent efficiency and viability, with standard deviations usually in the range of 2–3 percent. With its ability to transform bacteria and its ease of use, the system is suited for routine transfection experiments. The CLB-Transfection Device offers a menu of preset programs that allows easy optimization of transfection conditions and transformation of bacteria. The system consists of the CLB-Transfection Device combined with the CLB-Transfection Kit, which contains the CLB-Transfection Buffer and Cuvettes.

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