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Keeping Tabs on Tumor DNA

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Science  26 Feb 2010:
Vol. 327, Issue 5969, pp. 1074
DOI: 10.1126/science.327.5969.1074

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While many researchers are working on using tumor cells in blood to track cancer (see main text), a group at Johns Hopkins University has been doggedly pursuing a related idea: monitoring free-floating tumor DNA in blood. A new study being published in Science Translational Medicine this week suggests that advances in DNA sequencing may make this approach a strong alternative.