PerspectiveCell Biology

Turning Off Inflammation Signaling

Science  26 Feb 2010:
Vol. 327, Issue 5969, pp. 1093-1094
DOI: 10.1126/science.1187271

You are currently viewing the summary.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Summary

The name A20 may sound unassuming for a protein, but polymorphisms in the A20 gene locus have been identified as risk alleles for Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, type I diabetes, psoriasis, and atherosclerosis, suggesting important functions for A20 protein in autoimmunity. A20 is also a tumor suppressor for several types of B cell cancer, including Hodgkin's lymphoma and diffuse large B cell lymphoma (1). On page 1135 of this issue, Shembade et al. describe the means by which A20 acts through the transcription factor nuclear factor κB (NF-κB) to control inflammation (2).