PerspectiveCell Biology

Turning Off Inflammation Signaling

Science  26 Feb 2010:
Vol. 327, Issue 5969, pp. 1093-1094
DOI: 10.1126/science.1187271

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Summary

The name A20 may sound unassuming for a protein, but polymorphisms in the A20 gene locus have been identified as risk alleles for Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, type I diabetes, psoriasis, and atherosclerosis, suggesting important functions for A20 protein in autoimmunity. A20 is also a tumor suppressor for several types of B cell cancer, including Hodgkin's lymphoma and diffuse large B cell lymphoma (1). On page 1135 of this issue, Shembade et al. describe the means by which A20 acts through the transcription factor nuclear factor κB (NF-κB) to control inflammation (2).