Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells

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Science  19 Mar 2010:
Vol. 327, Issue 5972, pp. 1522-1526
DOI: 10.1126/science.1181759

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Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell division events and circadian phases of individual cells of the cyanobacterium Synechococcus elongatus and fit the data to a model to determine when cell cycle progression slows as a function of circadian and cell cycle phases. We infer that cell cycle progression in cyanobacteria slows during a specific circadian interval but is uniform across cell cycle phases. Our model is applicable to the quantification of the coupling between biological oscillators in other organisms.

  • * These authors contributed equally to this work.

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