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The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

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Science  26 Mar 2010:
Vol. 327, Issue 5973, pp. 1650-1653
DOI: 10.1126/science.1186624

Article Information

vol. 327 no. 5973 1650-1653

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 4, 2010
  • Accepted for publication February 26, 2010

Author Information

  1. Yingzi Wang1,
  2. Andrei V. Krivtsov1,
  3. Amit U. Sinha1,2,
  4. Trista E. North3,4,
  5. Wolfram Goessling4,5,6,
  6. Zhaohui Feng1,2,
  7. Leonard I. Zon1,4,7,
  8. Scott A. Armstrong1,2,4,*
  1. 1Division of Hematology/Oncology, Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Department of Pathology, Beth Israel Deaconess Hospital, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
  5. 5Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  6. 6Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  7. 7Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  1. *To whom correspondence should be addressed. E-mail: scott.armstrong{at}childrens.harvard.edu

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