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Science  26 Mar 2010:
Vol. 327, Issue 5973, pp. 1662
DOI: 10.1126/science.327.5973.1662-a

Cell-Based Image Analysis

The Cellomics Synaptogenesis High Content Screening (HCS) Reagent Kit enables simultaneous detection of neuronal population, neurite, presynaptic vesicle, postsynaptic puncta, and synapse through the use of a fixed end-point assay that is based on immunofluorescence detection in cells grown on standard high-density microplates. The kit is designed to enable drug discovery and systems biology researchers to measure synaptic function with sophisticated new technology. Offering simplicity and streamlined preparation of quality samples in the laboratory, the kit has been optimized for use with the Thermo Scientific ArrayScan HCS reader, which features the Neuronal Profiling BioApplication software module to identify the synapse measured by colocalization of the presynaptic marker with the postsynaptic marker. The kit works on all HCS platforms.

Microplate Sealer

The PlateLoc Thermal Microplate Sealer offers speed, a small footprint, ease of use, and dependability. It automatically accommodates deep well, assay, polymerase chain reaction, and compound storage microplates. Suitable for robotic integration, the PlateLoc Sealer features an extended-travel plate state, an RS-232 serial port, and ActiveX control. To minimize downtime when replenishing consumables, it features an easy-to-access, top-loading seal roll support. Three types of interchangeable sealing material are available: peelable, pierceable, or clear. The PlateLoc forms a consistent, high-integrity seal around each individual plate well. The thermal sealing mechanism leaves no waste seal material.

Liquid Chromatography System

The ÄKTA avant, the next-generation ÄKTA high-performance liquid chromatography system, provides a complete, robust solution for fast, scalable, and high-quality protein separations in process development. The built-in Unicorn 6 control system includes integrated design-of-experiments functionality to save time and increase productivity. The instrument's advanced configuration and flow and pressure capabilities enable the use of modern, high-flow BioProcess chromatography media, which can shorten process times by days and provide significant cost savings. The Unicorn 6 provides easy protocols transfer during scale-up and intuitive, flexible method editing. The system is compatible with HiScreen columns, which are prepacked with 19 different BioProcess media and have a bed height of 10 cm, suitable for method optimization and parameter screening.

LC Columns

Kinetex columns are ultrahigh performance liquid chromatography (UHPLC) columns based on new core-shell silica technology. With their speed and separation efficiency, Kinetex columns enable chromatographers to get performance comparable to that of sub-2-micron columns without investing in UHPLC systems. Kinetex columns allow researchers to achieve UHPLC results on any LC instrument platform, completing any chromatographic method in a fraction of the time previously required, without sacrificing performance. Their increased separation efficiencies also significantly reduce solvent usage and contribute to long column life. Kinetex core-shell technology enables high resolution and sensitivity over an extended linear velocity without generating excessive back-pressure.

Transmission Electron Microscopes

The corrected Libra 200 transmission electron microscopes (TEM) come in two configurations: the Libra 200 CES TEM is based on the energy-filter version of the 200 kV Libra TEM with a corrector for spherical aberrations of the objective lens. Through the use of this corrector, image resolution below 0.7 Å can be achieved. Applications that can benefit from this development include imaging of interfaces in semiconductors or solar cells, grain boundaries in steel alloys, and damage induced by nuclear radiation in shielding materials. In these applications, the control of the material at the atomic scale is necessary for in-depth understanding of the underlying physical or chemical processes and to guarantee the functionality of these devices. Another advantage of the corrector is the ability to reduce the acceleration voltage down to 80 kV and still achieve resolutions below 1 Å, which reduces beam damage for analysis of sensitive materials like carbon nanotubes.

Drug Discovery Database

The Collaborative Drug Discovery (CDD) database is a novel web-based platform to archive and mine a broad range of objects. The database allows a broad array of data types to be archived and kept private and secure. The data can be shared selectively among colleagues or openly on the Internet in standardized formats. The CDD platform incorporates physical chemical calculations, similarity and substructure searching, and Boolean search and save capabilities. It can handle diverse data files from instruments and individual experiments as well as CSV and SDK file-convertible formats.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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