PerspectiveImmunology

Salmonella Susceptibility

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Science  23 Apr 2010:
Vol. 328, Issue 5977, pp. 439-440
DOI: 10.1126/science.1189088

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Summary

Nontyphoidal Salmonella (NTS) are a group of enteric bacteria that cause self-limiting gastroenteritis in healthy individuals but can lead to life-threatening bacteremia in those with weakened immune systems. Before the introduction of highly effective antiretroviral therapy in 1995–1996, NTS bacteremia was a common opportunistic pathogen associated with HIV infection (1). Today, in countries with limited availability of antiretroviral therapy, NTS remains an important cause of morbidity and mortality in HIV-infected individuals (2). On page 508 of this issue, MacLennan et al. identify an immune response that allows NTS to thrive in individuals infected with HIV, thus causing the normal immune reaction to NTS infection to be defective (3). This may have important implications for the development of a vaccine against NTS.