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Science  30 Apr 2010:
Vol. 328, Issue 5978, pp. 640
DOI: 10.1126/science.328.5978.640-a

Benchtop Bath

The FTS Multi-Cool is a mechanically refrigerated benchtop bath that eliminates the need for costly consumables such as liquid nitrogen and dry ice. Compact and completely self-contained, the Multi-Cool provides up to 8 liters of working fluid volume at temperatures between –80°C and +100°C. The low temperature bath features precise control to within ±0.1°C.

Pluripotent Cell Medium

The FluoForte Calcium Assay Kit for monitoring calcium mobilization in live cells across a broad spectrum of biological targets contains the brightest and most sensitive fluorescent Ca2+ indicator on the market, according to the manufacturer. Featuring a large assay window, the FluoForte reagent can measure calcium changes in challenging cell lines and with difficult receptors, generating a strong green fluorescent signal. This homogeneous assay is suitable for analyzing both G protein-coupled receptor and calcium ion channel targets. The easy-to-use protocol does not require a wash step or the addition of a quencher dye that could potentially modify pharmacological parameters. The FluoForte dye can be loaded at 37°C or room temperature, which makes it amenable to high throughput screening applications.

Histological Examinations

The Leica SCN400 Slide Scanner offers an alternative to the microscope for the examination of histological samples in pathology, research, and teaching. The custom-tailored lens is designed for high-resolution scans to ensure that the resolution and color fidelity of the image on the screen are just as good as those of the microscope image. The system’s Dynamic Focus feature keeps the sample in focus for the full duration of the scan, so even difficult samples can be digitized easily. The Leica SCN400 can load and scan up to four specimens at a time. A scanning rate of 100 seconds per 15-mm-by-15-mm area at 20x magnification means sample throughput is high. The matching Leica SL801 autoloader can scan up to 384 samples at the same time, overnight if required, offering new options for automated operation.

Co-Immunoprecipitation Kit

The Pierce Co-Immunoprecipitation Kit is for the isolation of native protein complexes from a lysate or complex mixture using purified antibodies immobilized onto an agarose support. The kit makes use of an amine-reactive resin for the direct coupling of 10–50 micrograms of antibody. Traditional co-immunoprecipitation methods that rely on protein A or protein G result in co-elution of the antibody’s heavy and light chains, which may migrate with relevant bands, masking important results. The resin chemistry also enables immobilization independent of antibody isotype or species. The kit includes optimized buffers for protein binding and recovery, reagents to perform control experiments, and efficient spin columns and collection tubes that shorten the protocol and minimize handling.

Hydrogel Kit

The Extracel-SS Hydrogel Kit is an extracellular matrix designed to quickly and safely retrieve cells from encapsulation within the gel. The kit makes use of a fall-apart cross-linker that allows for dissolution of the hydrogel using a small amount of reducing agent. The gel is reconstituted by simply adding water to the three vials and mixing them together with desired cells. Gelation occurs in about 30 minutes.

Sequencing Computing

IlluminaCompute is an integrated computing solution for Illumina’s Genome Analyzer sequencing platform. The system brings together Illumina’s powerful sequencing software with high-performance blade servers from Dell and modular storage capacity from Isilon Systems to create a flexible and scalable system for human-scale genomic data analysis. The new system conserves information technology resources by providing centralized high-performance computational and storage infrastructure in place of the support required for individual, decentralized analysis servers. IlluminaCompute is a unique blending of hardware, informatics software, and high-availability storage that is tuned specifically for a high throughput sequence analysis workflow.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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