PerspectiveBiochemistry

Assembling the Outer Membrane

See allHide authors and affiliations

Science  14 May 2010:
Vol. 328, Issue 5980, pp. 831-832
DOI: 10.1126/science.1190507

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

Transmembrane proteins with β-barrel structure are characteristic of the outer membranes of Gram-negative bacteria, mitochondria, and chloroplasts (1). β-Barrel membrane proteins typically include a central pore that is lined by multiple antiparallel β strands. The functions of these proteins range from protein transport to metabolite flux. On page 890 of this issue, Hagan et al. (2) report a major step toward a molecular understanding of β-barrel membrane insertion and folding.