PerspectiveBiochemistry

Assembling the Outer Membrane

+ See all authors and affiliations

Science  14 May 2010:
Vol. 328, Issue 5980, pp. 831-832
DOI: 10.1126/science.1190507

You are currently viewing the summary.

View Full Text

Summary

Transmembrane proteins with β-barrel structure are characteristic of the outer membranes of Gram-negative bacteria, mitochondria, and chloroplasts (1). β-Barrel membrane proteins typically include a central pore that is lined by multiple antiparallel β strands. The functions of these proteins range from protein transport to metabolite flux. On page 890 of this issue, Hagan et al. (2) report a major step toward a molecular understanding of β-barrel membrane insertion and folding.