The ‘Do Unto Others’ Malaria Vaccine

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Science  14 May 2010:
Vol. 328, Issue 5980, pp. 847-848
DOI: 10.1126/science.328.5980.847

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Progress is accelerating on transmission-blocking vaccines (TBVs), which would use humans to generate antibodies and deliver them to mosquitoes, with the aim of preventing the insects from spreading the disease. A half-dozen TBVs could have a shot at clinical trials sometime in the next 5 years, researchers say. Even so, the scientific and social hurdles remain daunting. Key among them is whether people can be persuaded to get a vaccination that doesn't prevent them from getting sick but instead protects family and neighbors from getting infected. That also raises the bar for an extremely safe vaccine.