PerspectiveImmunology

The Origin of TH2 Responses

See allHide authors and affiliations

Science  28 May 2010:
Vol. 328, Issue 5982, pp. 1116-1117
DOI: 10.1126/science.1192009

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

Helper T lymphocytes (TH cells) have multiple functions during human immune responses, including stimulating B cells, the “help” needed to spur antibody production. Naïve TH precursor cells give rise to four functionally distinct subsets that can be further divided into subtypes or regulated states. Once the first two TH subsets were recognized—TH1 and TH2 cells (1)—the obvious question became: How does the immune system decide which response to make? Recent reports present an important advance in understanding the origins of TH2 responses and mechanisms of immune recognition of two medically important classes of antigens: helminth parasites and allergens.