PerspectiveCell Biology

Think Vesicular Chloride

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Science  11 Jun 2010:
Vol. 328, Issue 5984, pp. 1364-1365
DOI: 10.1126/science.1191529

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The distinction between passive and active ion movement through cellular channels and exchangers, respectively, has rarely been more relevant to understanding the physiological function of a protein than in the case of intracellular members of the chloride channel (CLC) family. Different CLC family members act either as chloride ion channels or as chloride-proton exchangers. On pages 1398 and 1401 of this issue, Novarino et al. (1) and Weinert et al. (2) demonstrate the relevance of the exchange activity in mammalian cells.