Tackling Two Diseases with HDL

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Science  25 Jun 2010:
Vol. 328, Issue 5986, pp. 1641-1642
DOI: 10.1126/science.1191663

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High-density lipoproteins (HDLs) transport cholesterol from peripheral tissues to the liver, helping to protect against diseases such as atherosclerosis. On page 1689 in this issue, Yvan-Charvet et al. present an entirely new role for HDL in regulating stem cell proliferation in the bone marrow (1). A relationship between cellular cholesterol content, HDL, and cells of the myelomonocytic lineage opens up the possibility that disorders characterized by the proliferation of immature white blood cells could be treated by targeting cholesterol transport in these cells.