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An Autophagy-Enhancing Drug Promotes Degradation of Mutant α1-Antitrypsin Z and Reduces Hepatic Fibrosis

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Science  09 Jul 2010:
Vol. 329, Issue 5988, pp. 229-232
DOI: 10.1126/science.1190354

Article Information

vol. 329 no. 5988 229-232

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Print ISSN: 
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History: 
  • Received for publication April 1, 2010
  • Accepted for publication May 21, 2010

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Author Information

  1. Tunda Hidvegi,
  2. Michael Ewing,
  3. Pamela Hale,
  4. Christine Dippold,
  5. Caroline Beckett,
  6. Carolyn Kemp,
  7. Nicholas Maurice,
  8. Amitava Mukherjee,
  9. Christina Goldbach,
  10. Simon Watkins,
  11. George Michalopoulos,
  12. David H. Perlmutter*
  1. Departments of Pediatrics, Pathology, Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 USA.
  1. *To whom correspondence should be addressed. E-mail: david.perlmutter{at}chp.edu

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