One-Two Punch Elevates Rats to the Knockout Ranks

See allHide authors and affiliations

Science  20 Aug 2010:
Vol. 329, Issue 5994, pp. 892
DOI: 10.1126/science.329.5994.892

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Last week, a group reported online in Nature about having successfully adapted to the rat the most widely used mouse knockout technique. This complements a different method for deleting rat genes described last year in Science. In addition to having two ways to knock out target genes, other groups have reported advances in techniques to produce transgenic rats as well as random knockouts that could be screened for interesting mutants.