Technical Comments

Response to Comment on “The Silicate-Mediated Formose Reaction: Bottom-Up Synthesis of Sugar Silicates”

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Science  20 Aug 2010:
Vol. 329, Issue 5994, pp. 902
DOI: 10.1126/science.1188978

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We reported that silicate mediates the formation of four-carbon and six-carbon sugars from simple two- and three-carbon molecules. Kim and Benner’s contention that silicate has little impact on these reactions is based on experiments using harsher conditions of temperature, pH, silicate concentration, and reaction time than in our study, thus confounding any comparisons between our results.

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