PerspectiveCell Biology

Nuclei Get TAN Lines

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Science  20 Aug 2010:
Vol. 329, Issue 5994, pp. 909-910
DOI: 10.1126/science.1194562

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The intracellular localization of the nucleus within a cell is tightly controlled and plays a central role in numerous cellular and developmental processes, including the establishment of cell polarity, fertilization, differentiation, and cell migration. Defects in nuclear movement or anchorage can disrupt development and cause disease. Many nuclear migration events involve the microtubule cytoskeleton. The nucleus is often led by the centrosome (the structure that organizes microtubules), and microtubule motors are recruited to the nuclear envelope (1). Other migrations use the actin cytoskeleton (2), but the mechanisms of actin-based nuclear migration have not been clear. On page 956 of this issue, Luxton et al. describe an actin network that moves nuclei (3).