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Science  20 Aug 2010:
Vol. 329, Issue 5994, pp. 972
DOI: 10.1126/science.329.5994.972-a


The PowerLyzer 24 benchtop, bead-based homogenizer is designed for powerful, fast, reliable homogenization and lysis of any biological sample. The bead beating instrument is capable of processing up to 24 samples in 2 ml tubes in as little as 30 seconds. With true hands-free operation, the downtime associated with manipulating samples through multiple cycles is eliminated. Even the toughest and most difficult to process samples such as pine needles, seeds, spores, fungal mats, and skin are easily and effectively lysed. Combined with MO BIO's line of high-quality nucleic acid isolation kits developed specifically for the PowerLyzer, the instrument yields substantial quantities of intact DNA and RNA for downstream analysis.

Gene and pathway-specific Assays

Fast, reliable, ready-to-use assays and reagents allow the customization of experiments based on the gene of interest. Explore and order gene and pathway-specific products for a range of applications using GeneGlobe, QIAGEN's web portal. For miRNA research, the miScript Target Protector is available for researchers doing functional analysis of miRNAs. The new FlexiTube siRNA Premix allows convenient one-step gene silencing in low throughput applications for analysis of gene function. For DNA methylation analysis, the PyroMark CpG and custom assays are available using Pyrosequencing technology. In addition, the PyroMark OneStep RT-PCR Kit enables the reverse transcription and subsequent amplification of RNA samples in the same tube.

DNA Sample Prep

The NEBNext products are a series of highly pure reagents that facilitate sample preparation for downstream applications, such as next generation sequencing. The NEBNext Quick DNA Sample Prep Reagent Set 2 and Master Mix Set 2 are suitable for library construction for the 454 GS FLX Titanium and GS Junior sequencing platforms. These sets provide all the necessary enzymes and buffers for fast fragment library preparation. The Master Mix Set further streamlines the workflow, reducing the number of vials by one-third. All reagents undergo stringent quality controls and functional validation by sequencing, ensuring maximum yield, convenience, and value.

DNA Copy Number Service

The Affymetrix Molecular Inversion Probe (MIP) Copy Number Service offers a convenient and reliable way for cancer researchers to get high-quality copy number data from formalin-fixed paraffin embedded (FFPE) samples. The MIP technology requires a small hybridizing footprint and as little as 75 ng of DNA, pairing well with the challenges of FFPE-archived samples, to examine more than 330,000 markers for good coverage across the genome. Because the MIP copy number application offers both allele and copy number data on a single platform, researchers now have a more comprehensive tool to evaluate risk factors for the early stages of cancer and disease relapse. The MIP also enables a more in-depth analysis of cancer, including copy-neutral loss of heterozygosity, levels of normal-tumor contamination, and preferential allele amplification.

laser scanning microplate cytometer

The Mirrorball is a high-sensitivity laser scanning microplate cytometer for antibody discovery and fluorescence cellular screening. This instrument rapidly and reliably performs mix-and-read, cell-, or bead-based assays and offers a simple and easy solution to automated hybridoma screening without requiring the reworking of existing protocols. Simultaneous laser scanning enables superior multiplexing, resulting in higher throughput single pass scanning. This instrument is available in three upgradable configurations; the highest specification will offer dual laser excitation (488 nm and 640 nm), four fluorescence data channels, and a single laser scatter channel. Mirrorball's laser scatter channel enables label-free object recognition independent of fluorescence, which can be combined with concurrent collection of fluorescence data for even greater sensitivity in


A range of acrylic radiation shielding products has been developed for use with beta or gamma emitting materials, including shields, boxes, racks, waste bins, spillage trays, and cabinets. Custom-built shields and boxes are manufactured in a variety of shapes and sizes to match any application or budget. The key features of these protective products are: clear optical construction for unobstructed view, choice of angle to suit location, availability of most shields in small and large sizes, large flat base models for under-bench protection and curved base models compatible with safety spill trays, plus boxes and bins available with hinged lids in a variety of designs and sizes. A DuoShield is available specifically for those applications which require safe protection from both beta and gamma emissions.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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