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Response to Comment on “The Human K-Complex Represents an Isolated Cortical Down-State”

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Science  01 Oct 2010:
Vol. 330, Issue 6000, pp. 35
DOI: 10.1126/science.1182204

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Our study confirmed the hypothesis of Amzica and Steriade that the human K-complex (KC) shares neural mechanisms with so-called slow oscillation between periods of intense neuronal firing and silence, but found that the KC can occur independently of this oscillatory activity. We agree with Amzica that the KC often has multiple components but contend that the major component is surface-negative and corresponds to the cortical down-state.

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