New Products

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Science  15 Oct 2010:
Vol. 330, Issue 6002, pp. 394
DOI: 10.1126/science.330.6002.394-a

PCR Consumables

The new white PCR consumables are designed to optimize results for real-time polymerase chain reactions (qPCR). Uniformly colored with Titanium dioxide, these PCR products offer significantly better results in the analysis of fluorescence signals and consequently with the quantification of the replicated DNA. Extra-thin wall dimensions provide optimal thermal transfer and short cycle times. Reflection of the fluorescence signal is optimized by smooth surfaces. The consumables are available in strips of 8-, 24-, 48-, 96-, and 384-well plates suitable for use in most thermal cyclers. Manufactured in clean room conditions these PCR products are DNase-, DNA-, and RNAse-free.

Real-Time PCR System

The Eco Real-Time PCR System is a novel platform that sets new standards in performance and simplicity for real-time polymerase chain reactions (qPCR), while offering unprecedented access to a wide range of applications at an affordable price. The Eco Real-Time PCR System offers true four-color multiplexing, high-resolution melting analysis (HRM), use of all standard qPCR chemistries, and the ability to perform fast PCR using standard chemistries. The Eco system has a compact design, 48-well plate format, and an intuitive, icon-driven software interface with smart default protocols. It offers ease-of-use for both experienced and novice qPCR users, and affordability to make it accessible to individual researchers around the world.

Double-Quenched Probe

A new double-quenched probe increases the accuracy and reliability of 5' nuclease real-time polymerase chain reaction (qPCR) experiments. While traditional probes have 20 to 30 bases between the dye and quencher, this novel proprietary probe design positions an internal ZEN quencher only 9 bases from the 5' fluorophore. This shortened distance, particularly when combined with the standard 3' quencher, significantly decreases background fluorescence and increases sensitivity. The chemical structure of the ZEN quencher stabilizes duplex formation which allows for its use in previously validated sequences. The improved functionality significantly increases qPCR accuracy and sensitivity when compared to traditional probes.

Thermal Cycler

The FC1 Cycler is designed to reduce thermal cycling time and reduce overall system configuration costs for researchers conducting high sample throughput single-nucleotide polymorphism genotyping. Adding this ultrafast thermal cycler to today's existing Fluidigm system offered, provides users with the ability to double the number of microfluidic chips that can be processed in a single day. The FC1 Cycler also integrates a self-contained vacuum source and touch screen interface (that offers easy editing of thermal protocols) in a streamlined design that minimizes lab space requirements while maximizing productivity. This thermal cycler is fully compatible with Fluidigm's 96.96 and 48.48 Dynamic Array IFCs and its 12.765 Digital Array IFC. When combined with either the Fluidigm EP1 Reader or BioMark Real-Time PCR system, the FC1 Cycler can complete the entire workflow of the system in a matter of hours with only minutes of hands-on time for loading the chips.

Segmented PCR plates

Twin.tec PCR plates are designed to be easily divisible to save material and money when running smaller-scale experiments. These segmented 96-well plates fit almost all available polymerase chain reaction instruments and can be snapped into four separate 24-well sections. Twenty-four, 48, or 72 wells can be used as required and the empty wells are saved for future use—reducing waste and bringing significant cost savings. The frame is manufactured from rigid polycarbonate for enhanced mechanical stability, while the flexible polypropylene wells are thin-walled to ensure a snug fit to the thermal block for optimal heat transfer. The inert surface of the wells prevents DNA, RNA, and enzymes from binding and improves recovery when working with small volumes.

PCR Arrays

Several new RT2 Profiler PCR Arrays are available for gene expression profiling in nephrotoxicity, hepatotoxicology, differentiation, and embryonic stem cells markers as well as analysis of epigenetic modulators and enzymes. The arrays make expression profiling accessible for routine use in every lab with a real-time polymerase chain reaction (qPCR) instrument. The experiment is simple to perform and provides sensitive, reproducible, and reliable results to accurately profile multiple genes simultaneously. The RT2 Profiler PCR Array provides gene expression data from the RNA within three hours and is composed of PCR Array plates, RT2 first strand kit, RT2 SYBR Green Master Mix, and the free PCR Array data analysis software.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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