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Genes Link Epigenetics and Cancer

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Science  29 Oct 2010:
Vol. 330, Issue 6004, pp. 577
DOI: 10.1126/science.330.6004.577

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Scientists haven't yet worked out exactly whether so-called epigenetic changes are a cause or a consequence of disease. That's one reason for skepticism about cancer treatments that target epigenetic features such as DNA methylation and chromatin structure (see main text). But recent reports that genes affecting the latter are mutated in several types of solid tumors could help resolve this conundrum.