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Lineage Relationship Analysis of RORγt+ Innate Lymphoid Cells

Science  29 Oct 2010:
Vol. 330, Issue 6004, pp. 665-669
DOI: 10.1126/science.1194597

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Abstract

Lymphoid tissue–inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORγt, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORγt+ innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORγt+ precursors. The fate of RORγt+ ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORγt+ T cells, however, RORγt+ ILCs develop in the absence of microbiota. Our study indicates that RORγt+ ILCs evolve to preempt intestinal colonization by microbial symbionts.

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