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LIFE SCIENCE TECHNOLOGIES: Structural Genomics Shapes Up Protein Research

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Science  29 Oct 2010:
Vol. 330, Issue 6004, pp. 689
DOI: 10.1126/science.330.6004.689


The three-dimensional structure of a protein determines how it works and interacts with other molecules. To understand complete pathways, processes, and eventually entire organisms, researchers need to know the structure of every protein. For the human proteome alone, researchers estimate that it consists of about one million proteins, when including all of the posttranslational modifications. Determining so many structures–plus millions more added from other organisms–depends on integrating a range of high throughput technologies.