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Science  12 Nov 2010:
Vol. 330, Issue 6006, pp. 912
DOI: 10.1126/science.330.6006.912-a

The Research Article “Reactome array: Forging a link between metabolome and genome” (1) described the synthesis of some 2000 quenched fluorescent dye-metabolite compounds, and their use to create an array to obtain a global overview of the metabolic network operating in a population of cells at the time of sampling. Upon productive interaction with an enzyme in a sample, an array compound releases the dye, which fluoresces and its signal is captured. To our profound regret, peer inspection of the paper after publication revealed errors and omissions in the information provided on the chemistry underlying array compound synthesis, and the processing of array data obtained. After an investigation, the Ethics Committee of the CSIC in Madrid has recommended the withdrawal of the paper. Given the errors in the paper, and the skepticism about the array that they have generated, we retract the paper. We apologize to Science, our institutions, and the scientific community for any inconvenience caused by our paper and its retraction.


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