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Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

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Science  12 Nov 2010:
Vol. 330, Issue 6006, pp. 980-982
DOI: 10.1126/science.1194516

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Abstract

The intracerebral injection of β-amyloid–containing brain extracts can induce cerebral β-amyloidosis and associated pathologies in susceptible hosts. We found that intraperitoneal inoculation with β-amyloid–rich extracts induced β-amyloidosis in the brains of β-amyloid precursor protein transgenic mice after prolonged incubation times.

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