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Science  12 Nov 2010:
Vol. 330, Issue 6006, pp. 990
DOI: 10.1126/science.330.6006.990-a

UV-Vis Spectroscopy

The Evolution 200 series of next generation UV-Visible spectrophotometers includes three instruments which satisfy specific applications from standard quantitative analysis to research life science assays. This series features the new INSIGHT software with customized user environment scripting capabilities. Designed for routine QA/QC analyses in the life science, food and beverage, and material science industries as well as offering fast data collection rates for kinetics measurements (up to 100 data points/sec), these instruments combine high performance and straightforward software, enabling personalized operation for greater productivity. The Evolution 200 series instruments feature high quality accessories and application specific technology to meet a wide range of sampling needs. Innovative Smart accessories enable accurate, cost-effective sample handling with automated software recognition and programmable control. Adding temperature control and fiber optic accessories can increase the instrument's productivity and extend sampling options.

Mitochondrial DNA Isolation

The XIT Mitochondrial DNA kit combines FOCUS Mitochondria technology with the XIT DNA isolation technology in a single kit. The kit supplies Subcell buffers to lyse cell and animal tissue in order to remove cellular proteins and nuclei from the highly enriched, intact, and active mitochondrial fraction. The mitochondria are then lysed with the included lysis buffer and treated with LongLife Proteinase K to degrade the proteins. Subsequently, mitochondrial DNA can be isolated using alcohol precipitation. The kit is designed for around 100 preparations consisting of 20x106 mammalian cells/prep. The XIT Mitochondrial DNA kit also contains protocols for isolation of mitochondria from soft (i.e. brain and liver) and hard (i.e. cardiac and skeletal muscle) tissue.

Fragment Library

The new Maybridge Ro3 Diversity Library has been computationally engineered to build on the key customer-driven features of the original Maybridge Ro3 Library, such as "Rule of Three" (Ro3) compliance, pharmacophoric enrichment, and quality assurance of at least 95 percent. The Maybridge Ro3 Diversity Library offers both an improved structural diversity profile and experimental solubility data for every one of the 1,500 member compounds. Full Ro3 compliance means that all 1,500 fragments have the physicochemical properties that increase the probability of successful "hits." The broad portfolio also provides access to analogues for fragment hopping, as well as reactive analogues for rapid hit evolution and derivatization. Consequently, these Maybridge Fragments provide an ideal starting point for a lead-optimization, structure-based drug discovery program, and the ultimate evolution of a new molecule in the drug discovery process. Every fragment in the new Maybridge library has been experimentally triaged to assure solubility in both dimethyl sulfoxide (200 mM) and aqueous phosphate buffer (1 mM).

microscopy image deconvolution

Designed to offer control and processing for microscope-based experimental systems, the cellSens Dimensions software package allows users to conduct a range of complex and highly sophisticated experiments, from extended focal imaging to multiple image alignment and multiple position imaging. The cellSens deconvolution solution module employs a constrained iterative algorithm to remove out-of-focus blur in advanced life science imaging. This high-speed operation provides extremely sharp images, as well as near confocal quality, with the ability to correct for any spherical aberrations. Integrating seamlessly with the cellSens Dimensions software, outstanding performance and quality are guaranteed. The resulting high-quality image stacks can be visualized in three dimensions, using the powerful VoxelViewer that shows structures, iso-surfaces, and projections. A broad range of image types can be deconvolved using the Olympus deconvolution solution module, including fluorescence, confocal, and brightfield.

Gel Documentation

The GENi is an affordable, fully motorized gel documentation system. This innovative system generates true 16-bit publication quality images of fluorescent and colored DNA and protein gels. Designed for simple, quick detection, the GENi gel documentation system is fitted with a fully motorized camera and zoom lens, providing a two megapixel resolution, as well as a six position motorized filter wheel, ensuring safe, hands-off imaging in seconds. GENi features a compact darkroom and built-in computer with a large touch screen, which means the system takes up minimal bench space while still offering users complete control of the camera, optics, and filters. The system's powerful integral processor allows users to generate, print, and save perfect gel and blot images

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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