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Science  03 Dec 2010:
Vol. 330, Issue 6009, pp. 1419
DOI: 10.1126/science.330.6009.1419-a

Microplate Reader

The Synergy H1 Hybrid is offered as a highly flexible, high value monochromator-based multi-mode microplate reader for ultraviolet-visible absorbance, top and bottom fluorescence, and luminescence assays. The modular architecture can be easily upgraded to a "hybrid" reader with the addition of a high performance filter module, offering true versatility and unlimited assay use. This independent filter module with dichroic mirrors supports fluorescence polarization (FP), time-resolved fluorescence (TRF), TR-FRET, and BRET assays with ultrahigh sensitivity. Synergy H1 includes the Gen5 Data Analysis Software for advanced reader control, data analysis, graphing, exporting, and reporting. Additionally, Synergy H1 is compatible with the Take3 Multi-Volume Plate that measures up to sixteen 2-μl samples, two BioCells, or a standard cuvette for fast and simple multivolume, multisample analysis.

Cell Health Analysis

FlowCellect kits are designed for cell health analysis using flow cytometry and allow researchers to quickly and easily evaluate mitochondrial health in drug compound screening, apoptosis-related research, and understanding the mechanism of diseases. The six new kits include the MitoDamage kit, which provides simultaneous information on mitochondrial perturbations, apoptosis, and cell death. The MitoStress kit allows study of the interrelationship between mitochondrial oxidative stress and apoptosis. For researchers who want to further understand mechanistic pathways, Cytochrome C kits allow for evaluation of mitochondrial Cytochrome C levels in apoptotic cells and commitment to the intrinsic pathway of death, thereby simplifying an assay that has traditionally been done with Western blots. The kits may be used on any flow cytometer equipped with blue and red lasers.

Low Evaporation Plates

Combining advanced optical properties with a low evaporation rate, Nunc Edge Plates enable researchers to obtain quality data from automated fluorescence imaging and quantitative analysis protocols. These plates incorporate large perimeter evaporative buffer zones that eliminate well-to-well variability, while dramatically reducing the overall plate evaporation rate to less than two percent after seven days of incubation. As a result, more viable and healthy cell yields are obtained. These zones enable the use of all 96 wells, greatly reducing the edge effect commonly experienced in cell culture, while maintaining data consistency throughout the plate. Nunc Edge Plates significantly reduce volume loss, effectively maintaining sample concentrations over long periods of incubation. The prevention of cell death and toxicity in the plates outer wells allows results to remain more true to the population phenotype for more efficient, high throughput analysis. Nunc Edge plates offer outstanding flatness and superior image quality, ideal for high content analysis applications and cell-based assays where multiple targets are simultaneously imaged.

Micropatterned Substrates

Patterns of extracellular matrix proteins can control important cellular functions including mitosis, apoptosis, cell growth, stem cell differentiation, tissue growth and structure, and multicellular dynamics and interactions. The new BioWrite line and grid protein micropatterns on glass coverslips are designed for cell-based applications. The fibronectin patterns have feature sizes ranging from 15 μm to 100 μm, which restrict the sites of cellular adhesion and spreading. The protein patterns can define the location, size, and morphology of cultured cells; control cellular functions; direct migration; and minimize variability in cell-based assays. The Substrate Design Center enables researches to rapidly develop custom protein micropatterns with features as small as 5 μm for specific cell-based applications. These products and services provide improved sensitivity, lower variability, and simpler automated image analysis for next generation cell-based assays.

Cell Culture Separation

FlexiPERM reusable silicone inserts can be used to subdivide slides and any cell culture dish into smaller cultivation units. Different cell lines can be grown in one vessel or equivalent cell lines can be grown in parallel with the assurance of comparable growth conditions. FlexiPERM inserts are highly adhesive to any flat surface for up to 14 days without additional—potentially contaminating—adhesives. After use, these inserts are easily removed without tools and may be sterilized and reused at least 10 times. Five versions of flexiPERM inserts are available. The flexiPERM slide and the flexiPERM micro 12 are ideally sized for microscope slides and feature eight and 12 cultivation wells, respectively. The flexiPERM disc provides four cultivation units and is appropriate for use with 60 mm dishes. FlexiPERM conA and conB inserts are single cone-shaped chambers suitable for micromanipulation and micro-injection applications.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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