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Science  10 Dec 2010:
Vol. 330, Issue 6010, pp. 1558
DOI: 10.1126/science.330.6010.1558-a

Protein G Biosensor

The Dip and Read Protein G biosensor can be used for rapid detection and quantification of numerous types of mammalian immunoglobulins (IgGs) from solution. Because it runs on the company's label-free Octet instrumentation platform, the new biosensor enables such measurements with unprecedented speed, ease-of-use, and cost-efficiency. The Protein G biosensor can be regenerated and reused for increased workflow flexibility and cost-efficiency. The biosensor comes with recombinant Protein G pre-immobilized on the surface and is ready-to-use on Octet instruments. All Octet biosensors are designed to simplify kinetic characterization and quantitation by eliminating throughput and time-to-result limitations of traditional surface plasmon resonance-based assays and enzyme-linked immunosorbent assays. The Octet biosensors are disposable, configured in a standard microplate format, and are coated with a proprietary biocompatible matrix that is uniform, non-denaturing, and has minimal nonspecific binding.

Yeast Protein Extraction

The YPX Yeast Protein Extraction Kit is unlike other yeast protein extraction products since it does not use mechanical disruption to break open the tough cell walls of yeast. Using the YPX kit is much faster than carrying out conventional yeast lysis procedures used for protein extraction, and results in a higher total protein yield. The protocol is simple and economical, and offers substantial usability and cost benefits to researchers who wish to carry out experiments on many yeast cultures simultaneously. The YPX Yeast Protein Extraction Kit allows extraction of the entire yeast proteome with nearly complete efficiency, and is uniquely compatible with quantitative yeast proteomics workflows, which would otherwise be complicated by day-to-day and lab-to-lab variations in protein extraction efficiencies. The economical kit contains sufficient material to extract proteins from 150 grams of spun-down, wet cell pellet yeast culture harvests. Starting material can be frozen or freshly harvested.

ChIP-Validated Antibodies

With Thermo Scientific Pierce Chromatin Immunoprecipitation (ChIP)-validated antibodies, researchers can obtain results more quickly by avoiding the testing of multiple antibodies to determine their suitability in ChIP assays. These antibodies are a perfect complement to the recently launched Thermo Scientific Pierce Agarose ChIP Kit. Thirty ChIP-validated antibodies are available to common targets, including numerous histone and transcription factor proteins.

Gel Documentation System

Gel Doc EZ is a compact gel documentation system that provides publication quality images and analysis in seconds—with just the push of a button—for researchers who perform DNA, RNA, and protein electrophoresis, as well as Western blotting. The Gel Doc EZ imager requires no training for first-time users and provides automated push-button functionality. This eliminates the need for researchers to manually manipulate filters, lenses, or lighting, thereby minimizing the potential for human error. In addition, the new system may be expanded to meet a variety of imaging applications. The imager allows the use of multiple application-specific trays, including a ultraviolet tray for imaging fluorescent stains such as ethidium bromide, a white tray for imaging colorimetric stains such as Coomassie blue, a blue tray for imaging SYBR Green-stained DNA, and a stain-free tray for imaging proteins separated by electrophoresis on Bio-Rad's Criterion TGX Stain-Free precast gels. The Gel Doc EZ imager is the only gel documentation system capable of imaging stain-free gels, an advanced gel technology that condenses traditionally long staining protocols down to a five-minute activation and imaging process.

Toxicity Detection

The MaxDiscovery Aspartate Transaminase (AST) and Lactate Dehydrogenase (LDH) Color Endpoint Assays use a proprietary, innovative technology for visible detection of in vivo toxicity using only 5 μL of serum from rodents or other mammals. These assays are powerful tools for the detection of drug-induced toxicity to the liver and heart can be used for preclinical testing in the drug discovery process. Both assays employ simplified endpoint analysis to offer high sensitivity, low detection limits, and the ability to use a visible plate reader. The MaxDiscovery AST kit permits quantitative visible determination of AST in a convenient format. Unlike traditional LDH tests, the MaxDiscovery LDH Color Endpoint Assay kit measures the direct chemical conversion of LDH and does not rely on coupled enzymatic amplification for high precision, quantitative measurements. Each kit contains ready-to-use product standards for the development of standard curves and accurate calibration of the assay.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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