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Science  21 Jan 2011:
Vol. 331, Issue 6015, pp. 347
DOI: 10.1126/science.331.6015.347-a

Automated Molecular Testing

The highly flexible and automated QIAsymphony RGQ is a novel, integrated system that sets new standards for molecular testing and incorporates all workflow steps from sample to detection. QIAsymphony offers many features that create exceptional flexibility, such as continuous loading, random access, open channels for user-developed tests, and the broadest menu of commercial assays as well as the ability to process an almost unlimited range of sample types. This new and complete workflow solution is composed of modules that can be used as stand-alone systems or combined into a fully integrated system. The QIAsymphony RGQ system comprises the physical and data integration of three modules: QIAsymphony SP for sample preparation, QIAsymphony AS for assay setup, and the Rotor-Gene Q real time polymerase chain reaction (PCR) thermocycler. QIAsymphony provides the broadest available PCR-based assay menu and offers workflow optimization with options for parallel runs and flexible batch sizes as well as intuitive, easy-to-use software.

Crimping Tool

The La-Pha-Pack stainless steel cleanroom crimping tools are designed for a controlled, low-effort method of vial sealing. Available in a range of sizes, from 11 mm to 20 mm, the optimal crimp is provided for a variety of vial sizes. Made entirely from stainless steel, it provides maximum durability and easily withstands dry heat sterilization or autoclaving. The product range is ideal for highly sensitive chromatography cleanroom applications where it is essential that the environment remains free from any potential contaminants. The mechanism of the La-Pha-Pack crimping tools is both corrosion- and heat-resistant, making it extremely durable with a long lifespan. Furthermore, the stainless steel construction removes the need for any protective coating on the handle or crimp head. Pressure and height of the La-Pha-Pack stainless steel crimping tools are easily adjustable, enabling optimal torque to be applied to a wide variety of vial styles.

lABel-FREE interaction ANALYSIS

The innovative SKi ProT X1000 biosensor instrument is the newest addition to the SKi Pro platform for label-free interaction analysis. The SKi Pro is the world�s only label-free biomolecular interaction analysis platform that allows experiments in multiwell plates and fine kinetic measurements in flow cells, all using the same reader instrument and the same surface chemistry. This unique dual-format feature can save time in overall protocol development, and enable uniformity and better correlation of experimental results across various departments in drug discovery and development. The technology making the dual-format feasible is nanopore optical interferometry. With integrated robotics, SKi ProT X1000 also automates experiments in a 96-well plate, all fluidics-free, with eight wells read at a time. Interaction analyses may be carried out at 15°C to 60°C, the widest range in the industry. In the flow cell mode, flow rates can be adjusted from 1 to 100 μl/minute

Cell Migration Assay

The new Oris Pro 384 Cell Migration Assay is designed specifically for fully automated high throughput screening using high-content screening and high-content imaging systems. The assay uses a non-toxic biocompatible gel (BCG) to form a centrally located and temporary cell-free zone on cell culture surfaces in a 384-well format. After cell seeding, the BCG dissolves and the migration of cells can be observed in the revealed detection zone, either in real time or after further experimental processing. This breakthrough product enables researchers to capture and quantify cell migration data while substantially improving assay efficiency and dramatically reducing assay costs. Measurement of cell migration enables researchers to better understand the impact of candidate therapeutic compounds on biological pathways and cellular behavior.

Melting Point Automation

The SMP40 melting point apparatus speeds up purity and identification testing by offering automatic, walk-away operation. The unit is available with optional full installation qualification and operation qualification (IQ/OQ) documentation. The SMP40 uses digital video imaging technology to detect and capture accurately the melting point of up to three samples simultaneously. The melt process can be viewed in real time or retrospectively on the full colour 5.7" VGA screen. Maximum footprint flexibility is ensured by the split design so, for example, the sample side of the apparatus can be placed at the back of the bench or even in a fume cupboard, while the control side detects whether it is being used upright or on its side and adjusts the screen orientation accordingly. Around 200 results in .avi video format of the melt process can be stored by the SMP40 for viewing on the unit's screen, while USB connectivity enables file transfer.

Automated Library Construction

SPRIworks Fragment Library System III automates the preparation of libraries for the Life Technologies SOLiD Sequencer. With the introduction of this third system in a series, researchers can use the SPRIworks system to automate library preparation for the three major next generation sequencing platforms. Combining Solid Phase Reversible Immobilization (SPRI) chemistry and Beckman Coulter automation, SPRIworks System III facilitates the construction of consistent, quality libraries. Automating the library construction process saves researchers valuable time. Between one and 10 samples can be completed within three and a half hours, and the process provides several size-selection and nick-translation options. SPRIworks Fragment Library System III is a validated plug-and-play system: users simply insert the method card, samples, and adapters; select the run options; and press start.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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