PerspectiveCell Biology

A Hand to Support the Implantation Window

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Science  18 Feb 2011:
Vol. 331, Issue 6019, pp. 863-864
DOI: 10.1126/science.1202372

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Reproduction in mammals is coordinated by an intricate sequence of events and signals that culminate in implantation of the embryo in the uterus (13). To succeed, these signals must be produced at the correct time, in the proper place, and in the amounts needed, and must be received by the appropriate targets. Perturbation of any of these factors can prevent establishment of pregnancy, resulting in infertility. On page 912 of this issue, Li et al. (4) show that the transcription factor Hand2 regulates signals that establish conditions in the mammalian uterus to support pregnancy.