New Epigenetic Drivers of Cancers

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Science  04 Mar 2011:
Vol. 331, Issue 6021, pp. 1145-1146
DOI: 10.1126/science.1203280

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Exome sequencing—the targeted sequencing of all protein-coding regions in the human genome—now offers an unprecedented opportunity for systematic, genome-wide discovery of somatic mutations in tumor tissue. On page 1199 of this issue, Jiao et al. (1) have applied this pioneering technique to identify common genetic mutations underlying pancreatic neuroendocrine tumors (PanNETs), a class of tumors that frequently arise from pancreatic islet cells. This report adds to a growing number of studies that use exome sequencing to explore cancers with unknown or poorly understood genetic etiology (28).