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A Bacterial Protein Targets the BAHD1 Chromatin Complex to Stimulate Type III Interferon Response

Science  11 Mar 2011:
Vol. 331, Issue 6022, pp. 1319-1321
DOI: 10.1126/science.1200120

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Abstract

Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)–stimulated genes (ISGs). IFN-λ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1+/– mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-λ−mediated immune response to control bacterial colonization of the host.

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