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Understanding HIV Latency to Undo It

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Science  13 May 2011:
Vol. 332, Issue 6031, pp. 786
DOI: 10.1126/science.332.6031.786

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Twenty-five years ago, when HIV still went by the names of HTLV-III and LAV, researchers recognized that the AIDS virus could lie dormant inside human chromosomes, which they erroneously suggested might explain the time lag between infection and disease. Today, with reservoirs of latently infected cells in the spotlight as the central obstacle to a cure (see main text), attention is focusing on the fine details of how HIV does this deep dive and stays submerged.