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Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution”

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Science  20 May 2011:
Vol. 332, Issue 6032, pp. 917
DOI: 10.1126/science.1187374

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Tan et al. (Reports, 25 September 2009, p. 1686) argued that loss of tyrosine residues from proteins in metazoans was driven by positive selection to remove potentially deleterious phosphorylation sites. We challenge this hypothesis, providing evidence that the high guanine-cytosine (GC) content of metazoan genomes was the primary driver in the loss of tyrosine residues.

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