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Response to Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution”

Science  20 May 2011:
Vol. 332, Issue 6032, pp. 917
DOI: 10.1126/science.1188535

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Abstract

Su et al. claim guanine-cytosine (GC) content variation can largely explain the observed tyrosine frequency variation, independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.

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