DNA Circles Cause Cow Coat Color Changes

Science  27 May 2011:
Vol. 332, Issue 6033, pp. 1030
DOI: 10.1126/science.332.6033.1030-a

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At the Biology of Genomes meeting, a geneticist reported what seems to be a new way that a cell shuffles its genes around: by forming a loop of DNA that then breaks apart in a different place before inserting into a different chromosome. So far, this circle-driven, gene-shuffling mechanism has been found only in cattle, but researchers are now wondering if it will prove to be common and are looking for examples in humans.