News FocusTHE BIOLOGY OF GENOMES

Disease Risk Links to Gene Regulation

Science  27 May 2011:
Vol. 332, Issue 6033, pp. 1031
DOI: 10.1126/science.332.6033.1031

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Summary

Researchers have been surveying regions of the human genome to identify functions of DNA outside the protein-coding portions of genes. They have, for example, generated genome-wide maps showing places where gene regulation occurs. Now, two teams at the Biology of Genomes meeting report that gene regulatory sites surprisingly often are the spots where single-nucleotide polymorphisms identified by genome-wide association studies fall.