PerspectiveBiochemistry

KSR Plays CRAF-ty

Science  27 May 2011:
Vol. 332, Issue 6033, pp. 1043-1044
DOI: 10.1126/science.1208063

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Summary

Organization of the bewildering array of known cell signaling proteins into coherent networks is facilitated by “scaffold” proteins that guide local information flow by binding multiple signaling molecules (1). Recent studies on one such scaffold protein called kinase suppressor of RAS (KSR), however, blur distinctions between the scaffold and the “scaffolded” by indicating that KSR itself has enzymatic activity that controls the signaling pathway assembled upon it (24).