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Science  27 May 2011:
Vol. 332, Issue 6033, pp. 1105
DOI: 10.1126/science.332.6033.1105-a

Miniaturized Chromatographic Columns

PreDictor RoboColumn units are miniaturized chromatographic columns prepacked with GE Healthcare BioProcess chromatography media to enable high throughput process development (HTPD). PreDictor RoboColumn units support fully automated chromatographic separation workflows using robotic liquid handling workstations. The prepacked columns are available with a wide range of chromatography resins for ion exchange, affinity, multimodal, and hydrophobic interaction chromatography techniques. PreDictor RoboColumn units are designed for parallel screening of chromatographic conditions. Each row of eight columns is supplied with one chromatography media and individual columns can be easily arranged on a 96-position array plate. The columns are available in 50, 200, and 600 μl volumes and are compatible with solutions commonly used in the purification of biopharmaceuticals.

Calibration Reagents

Four Thermo Scientific Pierce Calibration Solutions are now offered for calibration of Thermo Scientific Mass Spectrometers, including the Thermo Scientific LTQ Orbitrap series and the Thermo Scientific TSQ Vantage series. The Pierce Calibration Solutions are ready-to-use liquid formulations that consist of highly purified ionizable molecules that produce strong peaks. The four reagents include Pierce ESI Negative Ion Calibration Solution, Pierce LTQ ESI Positive Ion Calibration Solution, Pierce LTQ Velos ESI Positive Ion Calibration Solution, and Pierce Triple Quadrupole Calibration Solution. All calibration solutions are manufactured in an ISO 9001 environment with strict specifications in quality-controlled lots and are provided in leak-proof, high-purity PTFE bottles for easy storage.

Protein Sample Preparation

The Perfinity Workstation is a multicolumn apparatus that automates protein separations and mass spectrometry (MS) sample preparation for more efficient liquid chromatography/mass spectrometry (LC/MS) analysis. The Perfinity Workstation uses Shimadzu hardware components in conjunction with five Perfinity Optimized columns that each perform a step of the MS sample-preparation process—affinity selection, buffer exchange, digestion, desalting, and reverse-phase separation. The automated integration of these steps enables users to start with serum and have peptides ready for LC/MS analysis in 10 minutes. The automated process removes much of the equipment and labor associated with MS analyses of proteins. The Perfinity Workstation combines the selectivity of antibodies with the resolving power of chromatography. Buffer exchange and desalting are performed online. The reduction in sample-processing time enables users to screen a variety of conditions rapidly.

Lipid Characterization Software

SimLipid analyzes lipid mass spectrometric data for characterizing lipids, greatly advancing lipidome data analysis. SimLipid can annotate mass spectra with identified lipid structures and abbreviations as well. SimLipid profiles lipids by matching the experimental MS spectra with its own comprehensive, robust, and annotated database, consisting of nine lipid classes and 1948 lipid species. It retrieves lipids that correspond with the observed m/z and user specified filter criteria. Alongside the probable lipid structure important information such as the lipid ID, lipid abbreviation, systematic name, lipid category, lipid mass, chemical formula, and other database links is also made available. In addition, users can look up the database using lipid abbreviation, mass, chemical composition, or lipid ID.

Benchtop Mass Spectrometer

The Waters Xevo G2 Tof (time-of-flight) mass spectrometer with UPLC/MS and QuanTof technology offers the most sensitive, exact mass quantitative and qualitative performance of any benchtop mass spectrometer system for scientists who need to confidently identify and quantify unknown compounds in complex samples. Powered by QuanTof technology, the Xevo G2 Tof brings SYNAPT G2 technology in an accessible, benchtop system for a new level of quantitative and qualitative performance. QuanTof technology combines an innovative high-field pusher and dual-stage reflectron with a novel ion detection system in an optimized time-of-flight geometry. Together these features provide a new dimension of high resolution, exact mass and quantitative performance uniquely available at acquisition rates that are compatible with UPLC separations.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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