Technical Comments

Comment on “The Mechanism for Activation of GTP Hydrolysis on the Ribosome”

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Science  01 Jul 2011:
Vol. 333, Issue 6038, pp. 37
DOI: 10.1126/science.1202472

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Voorhees et al. (Reports, 5 November 2010, p. 835) determined the structure of elongation factor Tu (EF-Tu) and aminoacyl–transfer RNA bound to the ribosome with a guanosine triphosphate (GTP) analog. However, their identification of histidine-84 of EF-Tu as deprotonating the catalytic water molecule is problematic in relation to their atomic structure; the terminal phosphate of GTP is more likely to be the proper proton acceptor.

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