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Science  08 Jul 2011:
Vol. 333, Issue 6039, pp. 243
DOI: 10.1126/science.333.6039.243-a

DNA/RNA Transformation

The newly launched Eppendorf Eporator offers a fast, simple, and safe way to transform bacteria, yeast, and other microorganisms with DNA/RNA. Results are highly reproducible and, compared with chemical methods, electroporation yields to significantly higher transformation efficiency. Designed to deliver ideal conditions for electroporation of bacteria and yeast, the Eppendorf Eporator has been shown to give transformation efficiencies 10 times higher than with chemical transformation (heat shock method). The new Eppendorf Eporator not only saves valuable time and delivers higher transformation rates, but, crucially, the instrument is also extremely user friendly. Two new program buttons allow for storage and recall of the most commonly used parameters, and a simple one-button operation ensures intuitive use for faster sample handling. Eppendorf Eporator has a compact, space-saving design for easy storage and transport and comes with a USB port facilitating export of data for analysis and GLP-compliant documentation.

DNA Repair knockdown cell Lines

A range of highly efficient knockdown cell lines covering the base excision DNA repair pathway enable scientists to study the molecular etiology of tumor genomic instability and to exploit it for oncology research. The new range includes 20 DNA repair knockdown cell lines, which are based upon target-specific LN428 glioblastoma shRNA lentivirus-transduced cells that are rigorously qualified and mycoplasma free. DNA repair pathways maintain the integrity of the genome, reducing the onset of cancer, disease, and aging phenotypes. The DNA repair knockdown cell lines provide essential tools to address these needs. All DNA repair knockdown cell line products are evaluated by reverse transcription polymerase chain reactions (RT-PCR) and Western blot analysis, and functional assays are performed when feasible. The knockdown efficiency of the new DNA repair knockdown cell lines on target genes, as measured by RT-PCR, is 63 to 98%.

High throughput DNA labeling

New high throughput genomic DNA labeling kits and sample tracking spike-ins can further streamline workflow and minimize sample-tracking errors for researchers performing array comparative genomic hybridization (aCGH). The new CytoSure HT Genomic DNA Labeling Kit makes it possible to simultaneously label up to 96 samples using a 96-well plate format, boosting cost-effectiveness, increasing processing speed, and facilitating automated sample handling. The unique formulation and mastermix-based approach maximizes signal-to-noise ratio and reduces sample-to-sample variation, facilitating the confident detection of even the smallest aberrations. CytoSure ISCA Sample Tracking Spike-ins ensure that any potential sample mix-up during array processing can be easily identified, safeguarding against mistakes and maximizing data confidence. When used in combination with CytoSure ISCA arrays and the CytoSure Interpret Software, these new products make it easy to correlate individual data sets with sample origin.

High Throughput Sample Preparation

The Samplicity Filtration System is an innovative new technology that provides a convenient, high throughput alternative to syringe-tip filters when preparing samples for chromatography. The Samplicity system allows up to eight samples—even those with high viscosity or particulates—to be simultaneously vacuum-filtered in seconds. Samples are quickly and easily loaded using a pipettor and are filtered directly into LC vials. The filtered samples are immediately ready for subsequent analyses. The Samplicity system provides relief from the repetition of manual filtration and offers a throughput capacity well-aligned with the needs of most labs. The Samplicity system is designed for use with Millex Samplicity filter units with a hydrophilic Teflon membrane filter in either a 0.45 or 0.2 μm pore size. Millex Samplicity filter units have low extractables, low analyte binding properties, and a low hold-up volume, which allows processing of samples as small as 200 μL.

Plate Washer

The HydroSpeed plate washer is an advanced system optimized for washing of cells, beads, and enzyme-linked immunosorbent assays (ELISA) in 96- and 384-well formats. It offers full control over critical wash parameters via an intuitive touchscreen interface, with extra gentle drop-wise dispensing, and tunable aspiration settings to help avoid loss of material and maximize assay efficiency. The HydroSpeed features advanced Cell Protection settings for washing of adherent and loosely adherent cells, allowing the user to dial-in extra gentle wash parameters to suit their cells, microplates, and application. The system's innovative Anti-Clogging function takes the hassle out of ELISA washing by automatically rinsing and soaking the wash head when the system is idle between runs. The HydroSpeed uses two magnets per well for high performance magnetic bead washing, offering fast bead settling and excellent recovery rates, and can also be equipped with a vacuum filtration module for processing of nonmagnetic beads.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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