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Targeted Genome Editing Across Species Using ZFNs and TALENs

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Science  15 Jul 2011:
Vol. 333, Issue 6040, pp. 307
DOI: 10.1126/science.1207773

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Abstract

Evolutionary studies necessary to dissect diverse biological processes have been limited by the lack of reverse genetic approaches in most organisms with sequenced genomes. We established a broadly applicable strategy using zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) for targeted disruption of endogenous genes and cis-acting regulatory elements in diverged nematode species.

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